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I have made a fresh setup of macOS Big Sur, then upgraded to Monterey (12.3.1). Still experiencing the same issue with Xcode 13.3.1 and Instruments 13.3.1 (13E500a). As you can see in this picture the device is properly connected. If I open Console.app and filter process with instruments, with the device identifier, I can find two messages with AMDeviceStartSession (thread 0x16f7cf000): Could not start session with device b8e8692a880f964e92702f1da4066121c9e3252e: kAMDNotConnectedError

I have also this problem with Instruments tool in Xcode 12.4, Xcode 13.1 and Xcode 13.2.4 The device shows properly in the devices and simulators panel, and I'm able to run/debug the product. But when I try to run a leaks analysis the template selection panel says "No device" and the Instrument document gives an "unknown" device selection I tried to clean Developer folder cache, changing how I connect to the device (wirelessly, cable with internet sharing enabled or disabled), but nothing worked.