Hi Paul,
Something similar happened to me after upgrading my 2010 Macbook Pro with a Samsung 840 Evo.
El Capitan installed as expected, and ran for a few days without any problems. Then I experiened a system freeze and shut down with the power button. When I tried to reboot, nothing, just a grey screen. Eventually I got a circle with a line through it. I was able to boot into Recovery mode and then reinstall OSX not to the SSD but to my second hard drive. Once back in OSX, the SSD was recognized but it would not mount nor was Disk Utility able to repair it. Even DiskWarrior 5 (the only version to support Capitan) was not able to rebuild the drive directory and stated "Hardware failure (-5, 1921)."
Obviously with a relatively new SSD such as this one, hardware failure is extremely unlikely. I figured the behavior was a result of the upgrade and somehow related to Capitan's new TRIM support.
Online I read that the 840 Evo does not support Apple's TRIM without first flashing its firmware to the latest (EXT0DB6Q). Unfortunately, you need the Samsung Magician Tool to do this, and it's Windows only. (The alternative is making a firmware-flashing boot disk but getting that working on a Mac was too much of a pain.) Connecting it to a Windows computer at work with a spare SATA cable, I was able to inspect the drive with the Magician Tool. As expected, no hardware failure. SMART succeeded. It did however say that the drive had 0gb of usage, but I suspect that's because it couldn't read the HFS filesystem. So, I did the only thing I could do and flashed the firmware to latest.
Reconnecting to my Macbook, the drive was still not readable. I ran DiskWarrior again, however, and was now given the option to Rebuild its directory. But due to disk malfunction, it wasn't able to completely Repair the disk, merely gave me the option to Preview some of its recovered files and back them up.