I filed a bug report of this issue but I was curious to find out if others had the same problem:
I am using OS X El Capitan 10.11 (15A204h) and iTunes 12.2.0.145 (with Apple Music).
I've noticed several sound artifacts like skipping and such while listening to a streaming or downloaded song or music video. It seems to occur when I perform any workflow (clicking on a button, doing something in other applications) or at random (as if autonomous events and internal processes contributed to this).
These artifacts did not happen in the prior version of iTunes.
Thanks,
Mario