From what I have been reading, APFS changes how Fusion works. It's now just a cache repository for meta data, readback cache and writeback cache. It will assist in directory listing. App Nap, Prelinking and directory lookups would likely be the most impacted.
I do not know if it will offload files to the SSD that are frequently used like in days past. I'm not saying this is fact but supposition based on what little information I've found so far. The nature of APFS means it is always optimizing content in order to reduce fragmentation so logically it makes sense that it would work off of the HDD and use the Fusion as a cache - such as that for app nap.
Anyone else have insight on APFS and Fusion topology? Has it changed Fusion fundamentally?